The patients suffering from Covid-19 or Coronavirus can reach the tipping point which is when the patients start to experience symptoms that indicate that they would be dying says a report published recently.
As per the research, 1 in 7 patients would develop difficulty in breathing, organ failure and other severe complications which is when it turns critical. The patient will suffer from respiratory failure, vital organ failure which in turn makes the body go under septic shock said the report from WHO-China mission.
The progression of the disease can occur very quickly from mild to moderate to severe. About 10-15% of mild to moderate patients can progress to severe and 15-20% can progress to critical. Patients who are aged above 60 are at higher risk of going critical and those with underlying diseases such as Hypertension, Cardiovascular disease will be affected the most.
“The clinical picture suggests a pattern of disease that’s not dissimilar to what we might see in influenza,” said Jeffery K. Taubenberger, who also studied Spanish Flu outbreak
Covid-19 spreads through droplets that have been expelled from an infected person through cough, the infection generally starts in the nose, once inside the body the virus invades epithelial cells said Taubenberger, who heads the viral pathogenesis and evolution section of the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland.
Later the virus enters down the windpipe and then to the branches of respiratory lung tissue where it can quickly change into a severe form of infection. The severity can be caused by the body’s auto-immune response which may result in pneumonia. The body responds by releasing WBC’s which are the first line of defense and help heal the damaged tissues.
Normally if all goes well, the infection will be healed in a few days said Taubenberger. In severe cases, the body’s effort to heal goes haywire and that leads to the destruction of healthy cells too. Damage to epithelium causes loss of tiny hair that line the cells which can lead to overproducing mucus.
“You have no ability to keep stuff out of the lower respiratory tract,” Taubenberger said. And this can lead to potentially getting exposed to other virus/bacteria that is in our surrounding. And secondary bacterial infection means a threat to the respiratory cells and without them, you cannot physically repair the lungs, Damaged lungs can starve vital organs of oxygen, impairing the kidneys, liver, brain, and heart.
David Morens, senior scientific adviser to the director of the National Institute of Allergy and Infectious Diseases said “When you get a bad, overwhelming infection, everything starts to fall apart in a cascade,” he continued saying “You pass the tipping point where everything is going downhill and, at some point, you can’t get it back.”
Some people are genetically susceptible because they have an abundance of protein in their epithelial cells that the virus targets.